Ference was declared ready to go after missing the final nine games of the regular season because of a hernia.
The addition of Ference bolsters a depleted Bruins blue line. Defensemen Mark Stuart (finger) and Dennis Seidenberg (arm laceration) continue to be out.
The Sabres will be without two of their top six forwards Thursday. Jochen Hecht is out indefinitely after undergoing finger surgery, and Drew Stafford is still working his way back from a concussion sustained in the second-to-last game of the season.