Aruba Solicitor General Taco Stein made the announcement late this morning.
The bone is human, Stein said, but added that he could not say if it is from a male or female. One thing is certain: It is not that of Holloway, who disappeared May 30, 2005, at age 18 while on a trip to Aruba to celebrate her high school graduation.
"We could exclude that because from the dental records it was established that with Natalee, [her] wisdom tooth had been extracted, and in this bone there was a wisdom tooth present, so that made the exclusion possible," Stein said.
The news was yet another blow to the Holloways.
"We appreciate everyone's thoughts and prayers during this difficult time," Natalee's father, David Holloway, said in a statement, according to CNN. "We remain hopeful that someday we will have the answer to the whereabouts of our daughter, Natalee Holloway. We want to thank everyone for their support in our efforts to find justice. We ask that you continue to remember Natalee in your thoughts and prayers."
Beth Holloway, Natalee's mother, issued a statement to CNN through her lawyer, John Q. Kelly.
Stein said the bone had been in the water a long time. He also said investigators are checking to see if they have other missing persons they can compare the bone to.
Joran van der Sloot, a longtime suspect in the case, is behind bars in Peru, accused of the May 30 slaying of Stephany Flores. The Peruvian business student was found dead in van der Sloot's hotel room in Lima on June 2. Van der Sloot has been charged with first-degree murder and robbery in that case. If convicted of Flores' murder, he could face 15 to 35 years in prison.

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