In a speech in Louisville, Ky., Vice President Joe Biden called the events in Egypt "a pivotal moment in history" and said it was time to let the people of Iran speak out freely.
Later, speaking in his last news conference as White House press secretary, Robert Gibbs read from his briefing book to say the Iranian government is "quite frankly scared of the will of its people" in light of the call for democracy in Egypt.
"The Iranian government should allow the Iranian people to exercise the very same right of peaceful assembly and the ability to communicate their desires," as was demonstrated over the last 18 days in Egypt, Gibbs said.
"This is a major shift," said Michael Rubin, an expert on domestic politics in Iran and resident scholar at the conservative American Enterprise Institute. "Two things are happening: The administration is starting to be proactive rather than reactive, and the White House may have realized that moral clarity is the new realism. We are in a proxy war for influence with Iran whether we like it or not, and if this freedom wave hits Iran, it will only benefit the situation in the Middle East."
"How can they say anything else given events in Cairo?" said Aaron David Miller, a veteran Middle East peace negotiator to six U.S. secretaries of state.
The statements from the White House were hardly accidental. Today is the 32nd anniversary of Islamic Revolution in Iran. Tens of thousands jammed Tehran's main square to celebrate. Some of them burned effigies of Mubarak.
President Mahmoud Ahmadinejad, speaking before Mubarak stepped down, drew comparisons between the protests in Egypt and Iran's 1979 revolution.
He said "a new Middle East is emerging." However, given his crackdown on Iran's failed "Green Revolution" after elections in June 2009, it is clear he did not mean to include his own country.
Opposition leaders are expected to rally in Iran on Monday, said Alan Elsner of The Israel Project, a pro-Israel public affairs group.
"We'll see what happens -- but the regime is well-prepared to crack down," Elsner said. "Iran's leaders obviously fear the Iranian people will rise up to demand the same freedom the Egyptian people have grasped. No doubt their brutal militias are on high alert."
Follow Andrea Stone on Twitter

The Mortgage Mess: Just How Many Screwups Were There?




