The region from Kansas and Missouri southward to northern Texas and northern Louisiana will be the region most likely to be hit with damaging storms through tonight, including Kansas City, Oklahoma City and Dallas. The risk area will stretch from Oklahoma to Ohio on Friday and Friday night, encompassing St. Louis, Indianapolis, Nashville and Cincinnati.
The storms will be fueled by warm, humid air along the Gulf Coast -- highs in the 80s -- colliding with cooler, dry air from the Rockies -- highs in the 40s -- along with a potent late-season storm. This will be the fifth large-scale storm system to produce dangerous weather over multiple states and multiple days during April.

(Image courtesy of NOAA)
Wednesday's strong thunderstorms along the Eastern Seaboard and the Deep South pushed the number of preliminary severe weather reports to over 5,300 during April alone, according to the Storm Prediction Center. This includes over 450 reports of tornadoes.
The most devastating tornado outbreak -- one of the largest in U.S. history -- occurred earlier this week and killed 44 people from Oklahoma to North Carolina, according to the Los Angeles Times.
The most prolific outbreak, in terms of the number of reports, occurred early in the month, when more than 1,470 severe weather reports were tallied in 24 hours. Once all of these reports have been verified, the National Oceanic and Atmospheric Administration expects that this will be confirmed as a new 24-hour record. Such records have been kept since 2000.
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The most recent outbreak in the Midwest and Plains, from early Tuesday into early Wednesday, generated 930 reports, including 34 tornadoes.
Last year, the severe-weather season started much more slowly, with a total of 1,764 severe weather reports, including 197 tornadoes, during all of April.
Bouts of rain and thunderstorms will move into the mid-Atlantic region and Northeast on Friday and Saturday, where many rivers and streams are running high from recent rainfall.
This large-scale storm system will not be the last of the month, either. Additional storms will move through the Plains and Midwest from late in the weekend through much of next week, including the potential for more dangerous thunderstorms.

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